广西壮族人群微小RNA-30基因多态性分布特征及其与血脂水平的关系

罗艳萍; 刘潮; 谷嬉嬉; 陈健明; 蓝艳; 韦叶生

doi:10.16098/j.issn.0529-1356.2023.04.004

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解剖学报 ›› 2023, Vol. 54 ›› Issue (4) : 400-404. DOI: 10.16098/j.issn.0529-1356.2023.04.004

广西壮族人群微小RNA-30基因多态性分布特征及其与血脂水平的关系

罗艳萍¹ 刘潮¹ 谷嬉嬉¹ 陈健明¹ 蓝艳² 韦叶生^1*

作者信息 +

Distribution characteristics of polymorphisms of microRNA-30 gene in Guangxi Zhuang population and their association with serum lipid levels

LUO Yan-ping¹ LIU Chao¹ GU Xi-xi¹ CHEN Jian-ming¹ LAN Yan² WEI Ye-sheng^1*

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文章历史 +

摘要

目的探讨微小RNA(miR)-30基因单核苷酸多态性（SNP）位点rs1192037A/T在广西壮族人群中的分布特点，比较其与其他人群的多态性差异，并统计分析不同基因型的常见血脂检测项目水平。方法采用SNPscan技术检测236例广西壮族人群志愿者rs1192037A/T 位点基因型，分析其基因型和等位基因频率在不同性别和组间的分布差异，用罗氏全自动生化仪检测研究对象的常见血脂水平。结果 rs1192037A/T存在AA、AT 和 TT 3种基因型,其分布频率分别为 11.0%、38.6%和50.4%；rs1192037A/T的基因型和等位基因频率在不同性别间差异均无统计学意义(P>0.05);与人类基因组计划(HapMap)公布的欧洲人、日本人、非洲人、印第安人和墨西哥人分型数据相比较的SNP分型数据相比，其差异均具有统计学意义（P<0.05）；而与日本人和北京汉族人相比，其差异无统计学意义(P>0. 05)。rs1192037 A/T 3种基因型间TG的差异有统计学意义(P<0.05),且携带AT和TT基因型人群TG水平显著高于携带AA基因型人群。结论广西壮族人群 miR-30基因 rs1192037多态性在不同人群间存在不同程度差异；rs1192037A/T多态性与TG水平高低有关。

Abstract

Objective To explore the distribution situation of microRNA(miR) -30 gene single-nucleotide sites rs1192037A/T polymorphisms in Guangxi Zhuang population and compare its distribution differences with other populations and to analyze level of common blood lipid indexes in genotypes. Methods SNPscan was used to detect rs1192037A/T locus genotyping in 236 volunteers of Zhuang nationality in Guangxi. The genotypes and allele frequencies of rs1192037A/T locus genotyping in different genders and groups were analyzed. The levels of common blood lipids in the subjects were detected by roche automatic biochemical apparatus. Results Three genotypes of AA, AT and TT were found in rs1192037 A/T with the frequency distribution of 11.0%, 38.6% and 50.4%, respectively. No significant differences in genotypes and alleles frequencies of rs1192037 A/T between different genders in Guangxi Zhuang population were observed (P>0.05). However,there were significant differences in the genotype and allele frequency of miR-30 gene rs1192037 A/T in Guangxi Zhuang population compared with those of Europeans, Japanese, Africans, Mexicans and Indians published by HapMap (P<0.05), and there were not significant difference in genotypes and allele frequencies in population of HCB and JTP (P>0.05). There were significant differences in the levels of TG among the 3 genotypes of rs1192037 A/T, and the TG levels of AT and TT genotypes were significantly higher than AA genotypes. Conclusion There are different degrees of rs1192037 A/T polymorphisms of miR-30 gene among Guangxi population and other ethnic populations and other regions. The polymorphism of rs1192037 A/T is related to the level of TG.

导出引用

罗艳萍刘潮谷嬉嬉陈健明蓝艳韦叶生. 广西壮族人群微小RNA-30基因多态性分布特征及其与血脂水平的关系[J]. 解剖学报. 2023, 54(4): 400-404 https://doi.org/10.16098/j.issn.0529-1356.2023.04.004

LUO Yan-ping LIU Chao GU Xi-xi CHEN Jian-ming LAN Yan WEI Ye-sheng. Distribution characteristics of polymorphisms of microRNA-30 gene in Guangxi Zhuang population and their association with serum lipid levels[J]. Acta Anatomica Sinica. 2023, 54(4): 400-404 https://doi.org/10.16098/j.issn.0529-1356.2023.04.004

中图分类号： R394

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