脑血管发育的分子机制

张思琦; 康晨曦; 张佩艳; 雒海霞; 李飞; 史娟; 李云庆

doi:10.16098/j.issn.0529-1356.2022.05.022

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解剖学报 ›› 2022, Vol. 53 ›› Issue (5) : 680-686. DOI: 10.16098/j.issn.0529-1356.2022.05.022

综述

脑血管发育的分子机制

张思琦¹康晨曦¹ 张佩艳¹雒海霞¹ 李飞^2* 史娟^2* 李云庆²

作者信息 +

Molecular mechanism underlying vascular development in the brain

ZHANG Si-qi¹ KANG Chen-xi¹ ZHANG Pei-yan¹ LUO Hai-xia¹ LI Fei^2* SHI Juan^2* LI Yun-qing²

Author information +

文章历史 +

摘要

作为大脑中营养和氧气的输送管道，脑血管对大脑的发育及正常功能的发挥具有重要意义。脑血管系统的发育分为原始血管发生和血管生成两个过程。我们针对在上述过程中扮演重要角色的重要分子，如血管内皮生长因子（VEGF）、Neuropillin、Wnt、Notch、Hedgehog家族成员等在脑血管发生、形成和维持中的作用、调控机制和相互影响进行综述，以期为脑血管的基础研究和临床研究以及有关疾病的防治提供参考。

Abstract

As the pipelines of nutrient and oxygen in the brain, cerebral vessels play an important role in the development and normal function of the brain. The development of the cerebrovascular system is divided into two processes, primitive vasculogenesis and angiogenesis. In this review, we summarize the roles, regulation mechanisms, as well as the interactions of the essential signaling molecules, such as the family members of vascular endothelial growth factor (VEGF), neuropillin, Wnt, Notch, Hedgehog, in the vessel development, aiming to provide a reference for the basic and clinical investigation and the prevention and treatment of vascular diseases.

导出引用

张思琦康晨曦张佩艳雒海霞李飞史娟李云庆. 脑血管发育的分子机制[J]. 解剖学报. 2022, 53(5): 680-686 https://doi.org/10.16098/j.issn.0529-1356.2022.05.022

ZHANG Si-qi KANG Chen-xi ZHANG Pei-yan LUO Hai-xia LI Fei SHI Juan LI Yun-qing. Molecular mechanism underlying vascular development in the brain[J]. Acta Anatomica Sinica. 2022, 53(5): 680-686 https://doi.org/10.16098/j.issn.0529-1356.2022.05.022

中图分类号： R321 R34

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