MiR-429生物学功能的研究进展

郭建林; 王雪晴; 徐存拴

doi:10.16098/j.issn.0529-1356.2022.02.019

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解剖学报 ›› 2022, Vol. 53 ›› Issue (2) : 266-272. DOI: 10.16098/j.issn.0529-1356.2022.02.019

综述

MiR-429生物学功能的研究进展

郭建林^1,2* 王雪晴^1,2 徐存拴^1,2*

作者信息 +

Advances in biological functions of miR-429

GUO Jian-lin^1.2* WANG Xue-qing^1.2 XU Cun-shuan^1,2*

Author information +

文章历史 +

摘要

微小RNA（miRNA）是一类长度在22个核苷酸左右的内源性非编码单链RNA。这类RNA在细胞中发挥着重要的生物学功能，其中miR-429经大量研究证实，可以通过对不同靶基因的表达进行调控从而发挥抑制肿瘤发生和进展的重要作用，同时也能够在细胞分化和神经性疾病中发挥作用。我们对miR-429及其下游靶基因在细胞增殖、凋亡、迁移和侵袭中发挥的作用进行了概述。

Abstract

MicroRNAs (miRNAs, miR) are endogenous non-coding single-stranded RNAs with a length of about 22 nucleotides. These RNAs play an important biological function within cells, among which, miR-429 has been proved to play an important role in inhibiting tumor development and tumor progression as well as in cell differentiation and neurological diseases by regulating the expression of different target genes. In this paper, the role of miR-429 and its downstream targeted genes in cell proliferation, apoptosis, migration and invasion is summarized.

导出引用

郭建林王雪晴徐存拴. MiR-429生物学功能的研究进展[J]. 解剖学报. 2022, 53(2): 266-272 https://doi.org/10.16098/j.issn.0529-1356.2022.02.019

GUO Jian-lin WANG Xue-qing XU Cun-shuan. Advances in biological functions of miR-429[J]. Acta Anatomica Sinica. 2022, 53(2): 266-272 https://doi.org/10.16098/j.issn.0529-1356.2022.02.019

中图分类号： Q752

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