Nogo在心脏中的分布及其在心血管疾病中的作用

张苏欣; 孙艳荣; 王文娟; 孙昊哲; 胡耀文; 秦丽华

doi:10.16098/j.issn.0529-1356.2021.03.026

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解剖学报 ›› 2021, Vol. 52 ›› Issue (3) : 495-498. DOI: 10.16098/j.issn.0529-1356.2021.03.026

综述

Nogo在心脏中的分布及其在心血管疾病中的作用

张苏欣¹ 孙艳荣² 王文娟²孙昊哲³ 胡耀文¹ 秦丽华^2*

作者信息 +

Distribution of Nogo in the heart and its role in cardiovascular disease

ZHANG Su-xin¹ SUN Yan-rong² WANG Wen-juan² SUN Hao-zhe³ HU Yao-wen¹ QIN Lin-hua^2*

Author information +

文章历史 +

摘要

Nogo作为网状蛋白家族成员，主要参与组织损伤后再生、细胞凋亡和肿瘤生长等过程。心血管疾病是目前威胁人类健康的主要疾病之一。近年来关于Nogo在心血管系统的研究愈加广泛，在心肌纤维化、心肌细胞凋亡和血管重塑等病理过程中Nogo表达的变化提示其可能发挥一定的作用。本文中我们就Nogo在心脏中的分布及心血管疾病中作用作一综述，以揭示其在心血管疾病中可能的作用与机制。

Abstract

As a member of the reticulin family, Nogo is mainly involved in processes such as tissue regeneration, apoptosis and tumor growth after tissue injury. Cardiovascular disease is one of the main diseases that threaten human health at present. In recent years, research on Nogo in the cardiovascular system has become increasingly extensive. Changes in the expression of Nogo during myocardial fibrosis, myocardial cell apoptosis and vascular remodeling suggest that it may play a certain role. This article reviews the distribution of Nogo in the heart and its role in cardiovascular disease, in order to reveal its possible role and mechanism in cardiovascular diseases.

导出引用

张苏欣孙艳荣王文娟孙昊哲胡耀文秦丽华. Nogo在心脏中的分布及其在心血管疾病中的作用[J]. 解剖学报. 2021, 52(3): 495-498 https://doi.org/10.16098/j.issn.0529-1356.2021.03.026

ZHANG Su-xin SUN Yan-rong WANG Wen-juan SUN Hao-zhe HU Yao-wen QIN Lin-hua. Distribution of Nogo in the heart and its role in cardiovascular disease[J]. Acta Anatomica Sinica. 2021, 52(3): 495-498 https://doi.org/10.16098/j.issn.0529-1356.2021.03.026

中图分类号： R34

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