血清血管紧张素转换酶和血管紧张素原水平与妊娠高血压综合征的相关性及其危险因素

王茹; 庄文婷; 王香林; 李建华; 李红荣; 李长兴; 孔德霞

doi:10.16098/j.issn.0529-1356.2021.03.020

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解剖学报 ›› 2021, Vol. 52 ›› Issue (3) : 460-464. DOI: 10.16098/j.issn.0529-1356.2021.03.020

人类学

血清血管紧张素转换酶和血管紧张素原水平与妊娠高血压综合征的相关性及其危险因素

王茹¹庄文婷¹王香林² 李红荣³李长兴¹ 孔德霞⁴李建华^1*

作者信息 +

Correlation between serum angiotensin converting enzyme and angiotensinogen levels and pregnancy-induced hypertension and analysis of risk factors

WANG Ru¹ ZHUANG Wen-ting¹ WANG Xiang-lin² LI Hong-rong³ LI Chang-xing¹ KONG De-xia⁴ LI Jian-hua^1*

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文章历史 +

摘要

目的探讨血清中血管紧张素转换酶(ACE)和血管紧张素原 (AGT)与妊娠期高血压综合征（HDCP）的相关性及HDCP发病的危险因素。方法选择135例妊娠高血压患者（HDCP组）和100例正常孕妇（CK组），用ELISA法检测各组的血清ACE、AGT水平，并进行相关性分析；抽取两组孕产妇的年龄、怀孕天数、孕前体质量指数（BMI）、产次、产检次数、高血压糖尿病家族史、文化程度等一般资料，对孕产妇患HDCP的危险因素进行单因素分析，将单因素回归分析中有统计学意义的因素进行多因素 Logistic 回归分析。结果 HDCP组血清ACE水平（90.49±47.65）μg/L明显高于CK组（58.72±27.58）μg/L，P<0.05，差异有统计学意义；HDCP组血清AGT水平（64.57±19.71）μg/L高于CK组（58.22±18.64）μg/L，P>0.05,差异无统计学意义；单因素分析结果显示，年龄、BMI、高血压、糖尿病家族史、ACE水平是孕产妇患HDCP的危险因素（P<0.05），怀孕天数、产次、产检次数、文化程度比较差异无统计学意义（P>0.05）；多因素分析显示：年龄、BMI、高血压糖尿病史、ACE水平是妊娠性高血压的危险因素。结论 ACE水平与HDCP有关，AGT水平与HDCP无关；年龄大、BMI值高、有高血压糖尿病史者，ACE水平增高发生妊娠高血压综合征的风险增加。

Abstract

Objective To investigate the relationship between serum angiotensin converting enzyme (ACE) and angiotensinogen (AGT) and gestational hypertension syndrome (HDCP) and the risk factors of HDCP. Methods A total of 135 pregnant hypertensive patients (HDCP group) and 100 normal pregnant women as control check (CK) group were selected. Serum ACE and AGT levels were measured by ELISA, and correlation analysis was performed. The age and gestational age of the two groups, prepregnancy body mass index (BMI), parity, number of births, family history of hypertension, family history, education, and other general information, single factor analysis of risk factors for maternal HDCP, single factor regression analysis Statistically significant factors were all used for multivariate logistic regression analysis. Results The serum ACE level in the HDCP group (90.49±47.65)μg/L was significantly higher than that in the CK group (58.72±27.58)μg/L, P<0.05, the difference was statistically significant. The serum AGT level in the HDCP group was (64.57±19.71)μg/L was higher than CK group (58.22±18.64)μg/L, P>0.05, the difference was not statistically significant; single factor analysis showed: age, BMI, hypertension, family history of diabetes, ACE level was maternal (P<0.05), while gestational age, parity, number of births, and education were no significant differences in risk factors for HDCP (P>0.05). Multivariate analysis showed: age, BMI, history of hypertension and ACE. It was a risk factor for pregnancy-induced hypertension. Conclusion ACE levels are associated with HDCP. AGT levels are not associated with HDCP. Patients with a high age, high BMI, and hypertension history have an increased risk of gestational hypertension syndrome.

导出引用

王茹庄文婷王香林李红荣李长兴孔德霞李建华. 血清血管紧张素转换酶和血管紧张素原水平与妊娠高血压综合征的相关性及其危险因素[J]. 解剖学报. 2021, 52(3): 460-464 https://doi.org/10.16098/j.issn.0529-1356.2021.03.020

WANG Ru ZHUANG Wen-ting WANG Xiang-lin LI Hong-rong LI Chang-xing KONG De-xia LI Jian-hua. Correlation between serum angiotensin converting enzyme and angiotensinogen levels and pregnancy-induced hypertension and analysis of risk factors[J]. Acta Anatomica Sinica. 2021, 52(3): 460-464 https://doi.org/10.16098/j.issn.0529-1356.2021.03.020

中图分类号： R3

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