目的 探讨青海省汉族孕妇子痫前期（PE）与醛固酮合成酶基因（CYP11B2）启动子区单核苷酸多态性的关系。   方法  选择青海省PE患者149例，正常妊娠对照组155 例，应用聚合酶链反应-限制性内切酶片段长度多态性 (PCR-RFLP) 方法，分析PE组和对照组CYP11B2-344T/C多态性分型并测序验证。   结果  PE组基因型频率TT型、CT型及CC型分别为43.0%、45.6%和11.4%，对照组分别为51.0%、45.1%和3.9%。PE组和对照组醛固酮合酶基因-344T/C位点等位基因T和C频率分布具有差异性(P<0.05)，PE组C等位基因频率高于对照组（χ2=4.354，P<0.05, OR=0.691, 95% CI=0.49～0.98）。   结论  CYP11B2-344T/C多态性与青海省子痫前期有关，C等位基因可能是子痫前期的易感基因。

Objective  To investigate the relationship between preeclampsia (PE) and polymorphism of aldosterone synthase gene (CYP11B2) promoter region-344T/C in Qinghai Province.    Methods  A total of 120 PE subjects and 155 normal pregnancy subjects were studied. The genotype of CYP11B2 was analyzed by polymerase chain reaction fragment length polymorphism (PCR-RFLP)．The mutation was confirmed by sequencing.    Results  The frequencies of CYP11B2 TT, CT and CC genotype in the PE group were 43.0%, 45.6%, and 11.4%, and in the control group were 51.0%, 45.1%, and 3.9%, respectively. There was difference in frequency distribution of CYP11B2 genotype between the PE and control groups．The frequency of C allele in the PE group was higher than the control group（χ2=4.354，P<0.05, OR=0.691, 95% CI=0.49-0.98）.    Conclusion  The CYP11B2-344T/C polymorphism is related to preeclampsia in Qinghai Province, and the C allele may be a susceptibility gene of preeclampsia.