高孕激素状态促排卵方案与其他3种促排卵方案体外受精-冻融周期的结果比较

李建华; 焦婷婷; 王建业; 李常山; 董攀; 陈曦; 张水文

doi:10.16098/j.issn.0529-1356.2021.02.019

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解剖学报 ›› 2021, Vol. 52 ›› Issue (2) : 284-288. DOI: 10.16098/j.issn.0529-1356.2021.02.019

组织学胚胎学发育生物学

高孕激素状态促排卵方案与其他3种促排卵方案体外受精-冻融周期的结果比较

李建华¹ 焦婷婷¹ 王建业¹ 李常山¹ 董攀¹ 陈曦^2* 张水文^1*

作者信息 +

Outcomes of frozen-thawed embryo transfer cycles of progestin-primed ovarian stimulation protocol compared with other three ovulation hyperstimulation protocols

LI Jian-hua¹ JIAO Ting-ting¹ WANG Jian-ye¹ LI Chang-shan¹ DONG Pan¹ CHEN Xi^2* ZHANG Shui-wen^1*

Author information +

文章历史 +

摘要

目的比较高孕激素状态下促排卵（PPOS）方案与其他3种不同促排卵方案的实验室和临床妊娠结局。方法回顾性分析 2019年 6 月～ 2020 年 1 月在我院生殖中心行体外受精/卵泡浆内单精子显微注射（IVF/ICSI）共 430 个取卵周期和256个冻融周期，观察实验室相关数据、受精情况及妊娠结局的差异。结果取卵周期中，PPOS 方案 82 个，长方案 152个，短方案 116 个，拮抗剂方案 80 个。PPOS组获卵数（11.1±7.3）、受精率（85.6%）、卵裂率（95.1%）、可用胚胎数（4.5±3.1）、优质胚胎率（20.2%）等与其他3组之间差异均无统计学意义（P>0.05）。冻融周期中，PPOS 方案 27个周期，拮抗剂方案 107个，长方案 78 个，短方案 44 个。PPOS组种植率（26.2%）、临床妊娠率（63.0%）和流产率（11.8%）与其他各组比较差异无显著性（P>0.05），但临床妊娠率和种植率高于其他各组（P>0.05）。结论 PPOS方案和其他3种促排卵相比，对卵泡发育、卵母细胞和胚胎质量没有影响，而且临床妊娠率和种植率有升高的趋势，可以作为常规促排卵方案的一种新的选择。

Abstract

Objective To analyze the clinical outcomes of progestin primed ovarian stimulation (PPOS) compared with the other three different controlled ovarian hyperstimulation (COH) protocols in fresh embryo transfer (ET) and frozen-thawed embryo transfer (FET) cycles. Methods A total of 430 oocyte pickup cycles and 272 FET cycles were retrospectively analyzed. Number of oocytes retrieved, laboratory indexes and pregnancy outcome of FET were compared. Results The mean oocytes retrieved (11.1±7.3), fertilization rate (85.6%), cleavage rate (95.1%) and excellent embryo rate (20.2%) as well as transplantable embryo rate (4.5±3.1) of the PPOS group did not show significant differences compared with the other 3 subgroups (all P<0.05) in fresh cycle. As for pregnancy outcomes in FET cycles, no statistically significant differences were observed among the four groups in embryo implantation rate (26.2%), clinical pregnancy rate (63.0%) and abortion rate (11.8%) (all P<0.05)．However, embryo implantation rate, clinical pregnancy rate was higher in PPOS group compared with the other groups. Conclusion Conclusion Compared with the other three ovulation stimulation programme, PPOS might be used as a new alternative for controlled ovulation stimulation protocols.

导出引用

李建华焦婷婷王建业李常山董攀陈曦张水文. 高孕激素状态促排卵方案与其他3种促排卵方案体外受精-冻融周期的结果比较[J]. 解剖学报. 2021, 52(2): 284-288 https://doi.org/10.16098/j.issn.0529-1356.2021.02.019

LI Jian-hua JIAO Ting-ting WANG Jian-ye LI Chang-shan DONG Pan CHEN Xi ZHANG Shui-wen. Outcomes of frozen-thawed embryo transfer cycles of progestin-primed ovarian stimulation protocol compared with other three ovulation hyperstimulation protocols[J]. Acta Anatomica Sinica. 2021, 52(2): 284-288 https://doi.org/10.16098/j.issn.0529-1356.2021.02.019

中图分类号： R715

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