冠蛋白:肿瘤诊断的潜在靶点

林晨; 马琪; 王萍

doi:10.16098/j.issn.0529-1356.2020.03.026

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解剖学报 ›› 2020, Vol. 51 ›› Issue (3) : 461-468. DOI: 10.16098/j.issn.0529-1356.2020.03.026

综述

冠蛋白:肿瘤诊断的潜在靶点

林晨^1,2 马琪^2* 王萍^1*

作者信息 +

Coronin，a novel potential target in tumor

LIN Chen^1,2 MA Qi^2* WANG Ping^1*

Author information +

文章历史 +

摘要

冠蛋白 (coronin) 是位于细胞膜下方呈冠状结构的蛋白，由于它具备特殊的结构能与肌动蛋白结合，在胚胎发育和上皮细胞的迁移过程中扮演重要的角色。近年来随着对coronin家族研究的不断深入，发现其与微丝结合后能通过不同的分子机制影响肿瘤细胞的增殖和迁移；并且其表达水平的异常直接影响患者的预后。因此，对coronin的功能和分子机制的研究是目前的热点之一。我们将阐述coronin家族成员的结构特征及相应功能，总结并讨论其在当前各类肿瘤研究中的进展与潜在的应用前景。

Abstract

Coronin, a protein has a coronal-like pattern and locates below the cell membrane. Owing to its particular structure, coronin plays a key role in embryonic development and epithelial cell migration via its binding to microfilaments. Recently, proteins in coronin family were demonstrated that they could regulate the proliferation and migration of tumor cells through a series of molecular mechanisms, and there was a positive relationship between its abnormal expression and prognosis in the clinical patients. Therefore, its function and role in the progress of tumorigenesis is a hot topic in the current field of tumor research. In this paper, we made a comprehensive description of its molecular structural features, summarized its different roles in tumors, and predict its potential therapeutic prospects in the future.

导出引用

林晨马琪王萍. 冠蛋白:肿瘤诊断的潜在靶点[J]. 解剖学报. 2020, 51(3): 461-468 https://doi.org/10.16098/j.issn.0529-1356.2020.03.026

LIN Chen MA Qi WANG Ping. Coronin，a novel potential target in tumor[J]. Acta Anatomica Sinica. 2020, 51(3): 461-468 https://doi.org/10.16098/j.issn.0529-1356.2020.03.026

中图分类号： Q5 R73

参考文献

［1］ de Hostos EL, Bradtke B, Lottspeich F, et al., Coronin, an actin binding protein of dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits［J］. EMBO J, 1991, 10(13): 4097-4104.

［2］ Suzuki K, Nishihata J, Arai Y, et al., Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif［J］. FEBS Lett, 1995, 364(3): 283-288.

［3］ de Hostos EL. The coronin family of actin-associated proteins［J］. Trends Cell Biol, 1999, 9(9): 345-350.

［4］ Larsen NA, Harrison SC. Crystal structure of the spindle assembly checkpoint protein Bub3［J］. J Mol Biol, 2004, 344(4): 885-892.

［5］ Wilson DK, Cerna D, Chew E. The 1. 1-angstrom structure of the spindle checkpoint protein Bub3p reveals functional regions［J］. J Biol Chem, 2005, 280(14): 13944-13951.

［6］ Cheng Z, Liu Y, Wang C, et al. Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recombination［J］. Protein Sci, 2004, 13(10): 2673-2684.

［7］ Madrona AY, Wilson DK. The structure of Ski8p, a protein regulating mRNA degradation: implications for WD protein structure［J］. Protein Sci, 2004, 13(6): 1557-1565.

［8］ Appleton BA, Wu P, Wiesmann C. The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes［J］. Structure, 2006, 14(1): 87-96.

［9］ Goode BL, Wong JJ, Butty AC, et al. Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast［J］. J Cell Biol, 1999, 144(1): 83-98.

［10］ Mishima M, Nishida E. Coronin localizes to leading edges and is involved in cell spreading and lamellipodium extension in vertebrate cells［J］. J Cell Sci, 1999, 112 (Pt 17): 2833-2842.

［11］ Zeug A, Muller FE, Anders S, et al. Control of astrocyte morphology by Rho GTPases［J］. Brain Res Bull, 2018, 136: 44-53.

［12］ Swaminathan K, Muller-Taubenberger A, Faix J, et al. A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin［J］. Proc Natl Acad Sci USA, 2014, 111(1): E25-33.

［13］ Larkin MA, Blackshields G, Brown NP, et al. Clustal W and clustal X version 2.0［J］. Bioinformatics, 2007, 23(21): 2947-2948.

［14］ Ni HM, Qi DW, Mu H. Applying MSSIM combined chaos game representation to genome sequences analysis［J］. Genomics, 2018, 110(3): 180-190.

［15］ Asano S, Mishima M, Nishida E. Coronin forms a stable dimer through its C-terminal coiled coil region: an implicated role in its localization to cell periphery［J］. Genes Cells, 2001, 6(3): 225-235.

［16］ Gatfield J, Albrecht I, Zanolari B, et al. Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules［J］. Mol Biol Cell, 2005, 16(6): 2786-2798.

［17］ Rottmar M, Mhanna R, Guimond-Lischer S, et al. Interference with the contractile machinery of the fibroblastic chondrocyte cytoskeleton induces re-expression of the cartilage phenotype through involvement of PI3K, PKC and MAPKs［J］. Exp Cell Res, 2014, 320(2): 175-187.

［18］ Itoh S, Suzuki K, Nishihata J, et al. The role of protein kinase C in the transient association of p57, a coronin family actin-binding protein, with phagosomes［J］. Biol Pharm Bull, 2002, 25(7): 837-844.

［19］ Oku T, Nakano M, Kaneko Y, et al. Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin［J］. J Biol Chem, 2012, 287(51): 42910-42920.

［20］ Maniak M, Rauchenberger R, Albrecht R, et al. Coronin involved in phagocytosis: dynamics of particle-induced relocalization visualized by a green fluorescent protein Tag［J］. Cell, 1995, 83(6): 915-924.

［21］ Fukui Y, Engler S, Inoue S, et al. Architectural dynamics and gene replacement of coronin suggest its role in cytokinesis［J］. Cell Motil Cytoskeleton, 1999, 42(3): 204-217.

［22］ Williams HC, San Martin A, Adamo CM, et al. Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells［J］. Circ Res, 2012, 111(1): 56-65.

［23］ Tokarz-Deptula B, Malinowska M, Adamiak M, et al. Coronins and their role in immunological phenomena［J］. Cent Eur J Immunol, 2016, 41(4): 435-441.

［24］ Mori M, Pieters J. Getting in and staying alive: role for coronin 1 in the survival of pathogenic mycobacteria and naive T cells［J］. Front Immunol, 2018, 9: 1592.

［25］ Yan M, Di Ciano-Oliveira C, Grinstein S, et al. Coronin function is required for chemotaxis and phagocytosis in human neutrophils［J］. J Immunol, 2007, 178(9): 5769-5778.

［26］ Zare A, Mahmoodi M, Mohammad K, et al. A comparison between Kaplan-Meier and weighted Kaplan-Meier methods of five-year survival estimation of patients with gastric cancer［J］. Acta Med Iran, 2014, 52(10): 764-767.

［27］ Gadde R, Tamariz L, Hanna M, et al. Metastatic gastric cancer (MGC) patients: can we improve survival by metastasectomy? A systematic review and meta-analysis［J］. J Surg Oncol, 2015, 112(1): 38-45.

［28］ Ren G, Tian Q, An Y, et al. Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K［J］. Mol Cancer, 2012, 11: 67.

［29］ Sun Y, Shang Y, Ren G, et al. Coronin3 regulates gastric cancer invasion and metastasis by interacting with Arp2［J］. Cancer Biol Ther, 2014, 15(9): 1163-1173.

［30］ Benson AB, 3rd, Venook AP, Cederquist L, et al. Colon cancer, version 12017, NCCN clinical practice guidelines in oncology［J］. J Natl Compr Canc Netw, 2017, 15(3): 370-398.

［31］ Tamas K, Walenkamp AM, de Vries EG, et al. Rectal and colon cancer: Not just a different anatomic site［J］. Cancer Treat Rev, 2015, 41(8): 671-679.

［32］ Rastetter RH, Blomacher M, Drebber U, et al. Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling［J］. BMC Cancer, 2015, 15: 638.

［33］ Wu L, Peng CW, Hou JX, et al. Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation［J］. J Exp Clin Cancer Res, 2010, 29: 17.

［34］ Wu L, Cai C, Wang X, et al. MicroRNA-142-3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cells［J］. FEBS Lett, 2011, 585(9): 1322-1330.

［35］ Lim E, Lin NU. Updates on the management of breast cancer brain metastases［J］. Oncology (Williston Park), 2014, 28(7): 572-578.

［36］ Schmadeka R, Harmon BE, Singh M. Triple-negative breast carcinoma: current and emerging concepts［J］. Am J Clin Pathol, 2014, 141(4): 462-477.

［37］ Schneeweiss A, Denkert C, Fasching PA, et al. Diagnosis and therapy of triple-negative breast cancer (TNBC) -recommendations for daily routine practice［J］. Geburtshilfe Frauenheilkd, 2019, 79(6): 605-617.

［38］ Ge X, Lyu P, Cao Z, et al. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting［J］. Biochem Biophys Res Commun, 2015, 463(4): 1115-1121.

［39］ Kim DH, Bae J, Lee JW, et al. Proteomic analysis of breast cancer tissue reveals upregulation of actin-remodeling proteins and its relevance to cancer invasiveness［J］. Proteomics Clin Appl, 2009, 3(1): 30-40.

［40］ Wang J, Tsouko E, Jonsson P, et al. miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer［J］. Mol Oncol, 2014, 8(8): 1690-1702.

［41］ Hasse A, Rosentreter A, Spoerl Z, et al. Coronin 3 and its role in murine brain morphogenesis［J］. Eur J Neurosci, 2005, 21(5): 1155-1168.

［42］ Thal D, Xavier CP, Rosentreter A, et al. Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy［J］. J Pathol, 2008, 214(4): 415-424.

［43］ Ziemann A, Hess S, Bhuwania R, et al. CRN2 enhances the invasiveness of glioblastoma cells［J］. Neuro Oncol, 2013, 15(5): 548-561.

［44］ Pani A, Porta C, Cosmai L, et al. Glomerular diseases and cancer: evaluation of underlying malignancy［J］. J Nephrol, 2016, 29(2): 143-152.

［45］ Brehmer B, Kauffmann C, Blank C, et al. Resection of metastasis and local recurrences of renal cell carcinoma after presurgical targeted therapy: probability of complete local control and outcome［J］. World J Urol, 2016, 34(8): 1061-1066.

［46］ Atrih A, Mudaliar MA, Zakikhani P, et al. Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling［J］. Br J Cancer, 2014, 110(6): 1622-1633.

［47］ Xu Z, Zhai L, Yi T, et al. Hepatitis B virus X induces inflammation and cancer in mice liver through dysregulation of cytoskeletal remodeling and lipid metabolism［J］. Oncotarget, 2016, 7(43): 70559-70574.

［48］ Kumar P, Nandi S, Tan TZ, et al. Highly sensitive and specific novel biomarkers for the diagnosis of transitional bladder carcinoma［J］. Oncotarget, 2015, 6(15): 13539-13549.