更年期潮热的单胺类神经递质学说

孙艳荣 杨齐岳 李瑶 王文娟 王珂 秦丽华*

doi:10.16098/j.issn.0529-1356.2019.06.029

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解剖学报 ›› 2019, Vol. 50 ›› Issue (6) : 857-860. DOI: 10.16098/j.issn.0529-1356.2019.06.029

综述

更年期潮热的单胺类神经递质学说

孙艳荣¹ 杨齐岳¹李瑶²王文娟¹ 王珂¹秦丽华^1*

作者信息 +

Monoamine neurotransmitter theories of menopausal hot flashes

SUN Yan-rong¹ YANG Qi-yue¹ LI Yao² WANG Wen-juan¹ WANG Ke¹ QIN Li-hua^1*

Author information +

文章历史 +

摘要

潮热是更年期女性最常见的症状，并且其症状与心血管疾病的发生密切相关，严重影响着更年期女性的身心健康，因此，避免和减轻更年期潮热的发生已经成为当今倍受关注的课题。目前，普遍认为潮热是由下丘脑体温调节中枢功能紊乱所致，但其确切的发病机制尚未阐明。最近的研究相继表明，更年期潮热是雌激素与多种神经递质交互作用的结果，其中单胺类神经递质去甲肾上腺素、5羟色胺和多巴胺等起到了核心作用，现将其综述如下。

Abstract

Hot flashes are the most common symptoms of menopausal women, and their symptoms are closely related to the occurrence of cardiovascular disease, which seriously affects the physical and mental health of menopausal women. Therefore, avoiding and alleviating the occurrence of hot flashes during menopause has become a topic of great concern today. It is generally believed that the hot flashes are caused by the dysfunction of hypothalamic thermoregulatory center, but its exact pathogenesis has not been elucidated. Recent studies have shown that menopausal hot flashes are the result of the interaction of estrogen with a variety of neurotransmitters, and monoamine neurotransmitters like norepinephrine, 5-hydroxytryptamine and dopamine play a central role, which are summarized as follows.

导出引用

孙艳荣杨齐岳李瑶王文娟王珂秦丽华. 更年期潮热的单胺类神经递质学说[J]. 解剖学报. 2019, 50(6): 857-860 https://doi.org/10.16098/j.issn.0529-1356.2019.06.029

SUN Yan-rong YANG Qi-yue LI Yao WANG Wen-juan WANG Ke QIN Li-hua. Monoamine neurotransmitter theories of menopausal hot flashes[J]. Acta Anatomica Sinica. 2019, 50(6): 857-860 https://doi.org/10.16098/j.issn.0529-1356.2019.06.029

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