小鼠胚胎早期血细胞发生的研究进展

刘东华 何曦2 裴一岩 梁雨森 李凌衡* 刘慧雯* 

doi:10.16098/j.issn.0529-1356.2019.05.026

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解剖学报 ›› 2019, Vol. 50 ›› Issue (5) : 698-702. DOI: 10.16098/j.issn.0529-1356.2019.05.026

综述

小鼠胚胎早期血细胞发生的研究进展

刘东华¹ 何曦²裴一岩³ 梁雨森³ 李凌衡^2* 刘慧雯^1*

作者信息 +

Advances in the study of the murine hematopoiesis during the early stage of embryogenesis

LIU Dong-hua¹ HE Xi² PEI Yi-yan³ LIANG Yu-sen³ LI Ling-heng^2* LIU Hui-wen¹

Author information +

文章历史 +

摘要

根据时空上的不同，小鼠胚胎发育时期的血细胞发生目前被分为原始造血、红系/髓系祖细胞（EMPs）的产生和造血干细胞（HSCs）成熟并分化为各种血细胞3个阶段。最新的观点也把原始造血和EMPs的产生归结为非HSCs依赖性的血细胞谱系分化阶段，将第3阶段称为HSCs依赖性的血细胞谱系分化阶段。尽管胚胎时期的血细胞发生涉及多个造血器官，但本文中我们主要对近年在细胞和分子水平进行的造血细胞和HSCs在卵黄囊和腹主动脉-性腺-中肾（AGM）区发育的研究进行归纳总结，以此展示新近发现的胚胎发育早期血细胞发生的特点及其潜在机制。

Abstract

The development of the murine embryonic hematopoietic system occurs in spatially and temporally distinct waves, which it is described as three waves so far-primitive hematopoiesis, bipotential erythroid-myeloid progenitors (EMPs) generation and long-lived transplantable hematopoietic stem cells (HSCs) maturation from their precursors and differentiation toward all the adult lineages. The latest point is that HSC-independent hematopoietic lineages are produced in the primitive wave and definitive progenitor wave in the early mammalian embryo, such as primitive erythrocytes or EMPs. The HSC-dependent phase of hematopoietic development produces all the adult lineages derived from HSCs. In this review, the recent studies on the development of hematopoietic cells and HSCs in the yolk sac and aorta-gonad-mesonephron region (AGM) region at cellular and molecular level will be summarized to provide an integrated model of developmental hematopoiesis, although multiple hematopoietic sites are involved in ebryonic hematopoiesis. It may offer new insights into the characteristics and its underlying mechanism of hematopoiesis at the early stage of embryogenesis.

导出引用

刘东华何曦2 裴一岩梁雨森李凌衡刘慧雯. 小鼠胚胎早期血细胞发生的研究进展[J]. 解剖学报. 2019, 50(5): 698-702 https://doi.org/10.16098/j.issn.0529-1356.2019.05.026

LIU Dong-hua HE Xi PEI Yi-yan LIANG Yu-sen LI Ling-heng LIU Hui-wen. Advances in the study of the murine hematopoiesis during the early stage of embryogenesis[J]. Acta Anatomica Sinica. 2019, 50(5): 698-702 https://doi.org/10.16098/j.issn.0529-1356.2019.05.026

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