目的 探讨含微乳头结构（MPP）肺腺癌具有的CT重建征象特征，上皮间质转化（EMT）相关分子表达情况以及它们之间的关系。 方法 选取含MPP侵袭性肺腺癌（IAC）37例、不含MPP 80例及其对应的癌旁组织，比较临床病理特征、CT重建征象；应用Real-time PCR及Western blotting检测EMT有关标识分子表达变化情况。 结果 含MPP组淋巴结转移比例较高、毛刺、胸膜凹陷征、实性及分叶比例较高（均P<0.001）。 含MPP组E-钙黏蛋白（cadherin）及β-连环蛋白（β-catenin）表达均下调（P<0.05），N-cadherins、波形蛋白（vimentin）、Snail及转化生长因子（TGF）-β表达均上调（P<0.05）。有毛刺组Ecadherin及β-catenin表达下调者所占比例较高，而vimentin表达上调者所占比例较高（均P<0.05）；实性结节组E-cadherin表达下调者所占比例较高，而N-cadherin及vimentin表达上调者所占比例较高（均P<0.05）。 结论 含MPP浸润性肺腺癌具有特征性CT重建征象，发生了EMT改变。其CT重建征象与EMT相关分子表达存在联系。

Objective To investigate the features of CT reconstruction imags, expressions of genes associated with epithelial-mesenchymal transition(EMT) in lung adenocarcinoma with micropapillary pattern (MPP) and the relationships between them. Methods Thirty-seven cases of invasive lung invasive adenocarcinoma (IAC) with MPP, 80 cases without MPP and their corresponding para-cancerous tissues were selected. The clinicopathological features and features of CT reconstruction images were compared. Real-time PCR and Western blotting were used to detect the expression of EMT markers. Results In MPP group, the proportions of lymph node metastasis, spicule, pleural indentation, solid type and lobulation were higher（P<0.001）.In MPP group, the expressions of E-cadherin, β-catenin were decreased（P<0.05）, and the expressions of N-cadherin, vimentin,Snail and transforming growth factor(TGF)-β were increased（P<0.05）. In spicule group, the percentage of decreased expression of E-cadherin and β-catenin was higer, while the percentage of increased expression of vimentin was higher（P<0.05）. In the group of solid type, the percentage of decreased expression of E-cadherin was higher, while the percentages of increased expression of N-cadherin and vimentin were higher（P<0.05）. Conclusion Lung invasive adenocarcinoma has characteristics of CT reconstruction images and EMT changes. CT reconstruction images are associated with the expression of the related molecules associated of EMT.