神经烯醇化酶与中枢神经系统发育、损伤修复的研究进展

周静莹 张宋欧 孟晓芳 刘学红*

doi:10.16098/j.issn.0529-1356.2018.03.021

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解剖学报 ›› 2018, Vol. 49 ›› Issue (3) : 395-399. DOI: 10.16098/j.issn.0529-1356.2018.03.021

综述

神经烯醇化酶与中枢神经系统发育、损伤修复的研究进展

周静莹张宋欧孟晓芳刘学红*

作者信息 +

Research progress of neuron specific enolase in development，injury and repair of the central nervous system

ZHOU Jing-ying ZHANG Song-ou MENG Xiao-fang LIU Xue-hong*

Author information +

文章历史 +

摘要

神经烯醇化酶（NSE）作为神经元发育、重塑的特异性标志物，在中枢神经系统发育和损伤修复过程中呈时空性表达分布。损伤后NSE的改变可以反映病理变化，通过调节NSE水平可以达到损伤后的修复效果，对神经系统的损伤修复有重要意义。本文中我们就NSE的分子结构、表达调控、生物学功能及其与中枢神经系统发育、损伤修复关系进行综述。

Abstract

As a specific marker of neuron development and reconstruction, neuron specific enolase (NSE) expresses the spatiotemporal distribution in the development and repair of central nervous system. The change of NSE after central nervous system injury can reflect the pathological changes, and can adjust the level of NSE to achieve the effect of post injury repair. It is important for the repair and damage of the nervous system. In this review, we review the molecular structure, expression regulation, biological function of NSE and its relationship with the development, injury and repair of the central nervous system.

导出引用

周静莹张宋欧孟晓芳刘学红. 神经烯醇化酶与中枢神经系统发育、损伤修复的研究进展[J]. 解剖学报. 2018, 49(3): 395-399 https://doi.org/10.16098/j.issn.0529-1356.2018.03.021

ZHOU Jing-ying ZHANG Song-ou MENG Xiao-fang LIU Xue-hong. Research progress of neuron specific enolase in development，injury and repair of the central nervous system[J]. Acta Anatomica Sinica. 2018, 49(3): 395-399 https://doi.org/10.16098/j.issn.0529-1356.2018.03.021

参考文献

［1］Kumar A, Stoica BA, Loane DJ, et al. Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury［J］. J Neuroinflammation, 2017,14(1):47.

［2］Gadani SP, Walsh JT, Lukens JR, et al. Dealing with danger in the CNS: the response of the immune system to injury［J］.Neuron, 2015, 87(1):47-62.

［3］Marquardt G, Setzer M, Theisen A, et al. Experimental subacute spinal cord compression: correlation of serial S100B and NSE serum measurements, histopathological changes, and outcome［J］.Neurol Res,2011,33(4):421-426.

［4］Hajduková L, Sobek O, Prchalová D, et al. Biomarkers of brain damage: S100B and NSE concentrations in cerebrospinal fluid-A normative study ［J］.Biomed Res Int, 2015, 2015(4):379071.

［5］Calderon LM, Guyette FX, Doshi AA, et al. Combining NSE and S100B with clinical examination findings to predict survival after resuscitation from cardiac arrest［J］. Resuscitation，2014，85(8):1025-1029.

［6］Sahu S, Nag DS, Swain AA, et al. Biochemical changes in the injured brain［J］. World J Biol Chem，2017，8(1):21-31.

［7］Stammet P. Blood biomarkers of hypoxic-ischemic brain injury after cardiac arrest［J］. Semin Neurol, 2017, 37(1):75-80.

［8］Fink EL, Berger RP, Clark RS, et al. Serum biomarkers of brain injury to classify outcome after pediatric cardiac arrest ［J］. Crit Care Med, 2014, 42(3):664-674.

［9］Mendes AA, de Souza LF, Walz R, et al. Perspectives on molecular biomarkers of oxidative stress and antioxidant strategies in traumatic brain injury［J］. Biomed Res Int, 2014, 2014(1):63-68.

［10］Chai G, Brewer JM, Lovelace LL, et al. Expression, purification and the 1.8 angstroms resolution crystal structure of human neuron specific enolase［J］.J Mol Biol, 2004, 341(4):1015-1021.

［11］Sakimura K, Kushiya E, Takahashi Y, et al. The structure and expression of neuron-specific enolase gene［J］. Gene, 1987,60(1): 103-113.

［12］Forss-Petter S, Danielson PE, Catsicas S, et al.Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control［J］.Neuron,1990,5(2): 187-197.

［13］Vizin T, Kos J. Gamma-enolase: a well-known tumour marker, with a less-known role in cancer ［J］.Radiol Oncol, 2015,49(3):217-226.

［14］Hafner A, Obermajer N, Kos J. γ-Enolase C-terminal peptide promotes cell survival and neurite outgrowth by activation of the PI3K/Akt and MAPK/ERK signalling pathways［J］.Biochem J, 2012, 443(2):439-450.

［15］Henshall DC, Araki T, Schindler CK, et,al. Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death［J］. J Neurosci, 2002,22(19):8458-8465.

［16］Yuki Fujita TY. Axon growth inhibition by RhoA/ROCK in the central nervous system［J］. Front Neurosci, 2014, 8:338.

［17］Wu YL, Maachani UB, Schweitzer M, et al. Dual Inhibition of PI3K/AKT and MEK/ERK pathways induces synergistic antitumor effects in diffuse intrinsic pontine glioma cells［J］. Transl Oncol, 2017, 10(2):221-228.

［18］Isqro MA, Bottoni P, Scatena R. Neuron-specific enolase as a biomarker: biochemical and clinical aspects［J］. Adv Exp Med Biol, 2015, 867:125-143.

［19］Soh M, Dunlevy JR, Garrett SH, et al. Increased neuron specific enolase expression by urothelial cells exposed to or malignantly transformed by exposure to Cd2+ or As3+［J］. Toxicol Lett, 2012, 212(1): 66-74.

［20］Muller FL, Colla S, Aquilanti E, et al. Passenger deletions generate theraqeutic vulnerabilities in cancer［J］.Nature, 2012,488(7411):337-342.

［21］Moreno-Rius J, Miquel M. The cerebellum in drug craving［J］. Drug Alcohol Depend, 2017, 173:151-158.

［22］Menghi F, Jacques TS, Barenco M, et al. Genome-wide analysis of alternative splicing in medulloblastoma identifies splicing patterns characteristic of normal cerebellar development［J］. Cancer Res, 2011, 71(6):2045-2055.

［23］Lossi L, Ghidella S, Marroni P, et al, The neurochemical maturation of the rabbit cerebellum ［J］. J Anat,1995,187(3): 709-722.

［24］Nishimura M, Takashima S, Takeshita K, et al. Developmental changes of neuron-specific enolase in human brain: an immunohistochemical study［J］.Brain Dev,1985,7(1): 1-6.

［25］Hou N, Gong M, Bi Y, et al. Spatiotemporal expression of HDAC2 during the postnatal development of the rat hippocampus［J］. Int J Med Sci, 2014, 11(8):788-795.

［26］Mareschi K, Novara M, Rustichelli D, et al. Neural differentiation of human mesenchymal stem cells: evidence for expression of neural markers and eag K+, channel types［J］. Exp Hematol, 2006, 34(11):1563-1572.

［27］Schmechel DE, Brightman MW, Marangos PJ. Neurons switch from non-neuronal enolase to neuron-specific enolase during differentiation［J］. Brain Res, 1980, 190(1):195-214.

［28］Marangos PJ, Schmechel DE, Parma AM, et al. Developmental profile of neuron-specific (NSE) and non-neuronal (NNE) enolase［J］. Brain Res, 1980, 190(1):185-193.

［29］Vinci L, Ravarino A, Fanos V, et al. Immunohistochemical markers of neural progenitor cells in the early embryonic human cerebral cortex［J］. Eur J Histochem, 2016, 60(1):2563.

［30］Hafner A, Glavan G, Obermajer N, et al. Neuroprotective role of gamma-enolase in microglia in a mouse model of Alzheimer’s disease is regulated by cathepsin X［J］. Aging Cell, 2013, 12(4): 604-614.

［31］Kato M, Takashima S. Immunohistochemical and morphometrical development of the dorsal root ganglion as a neural crest derivative: comparison with the fetal CNS［J］. Early Hum Dev, 1994, 38(2):81-90.

［32］Liu XH, Zhang Y, Chen JE. Expression of neuronal nuclear antigen and neuron-specific enolase in the developing spinal cord of human embryos［J］.Acta Anatomica Sinica,2013,44(5):694-698.(in Chinese)

刘学红,张泳,陈健尔. 神经元核心抗原和神经元特异性烯醇化酶在人胚胎脊髓发育阶段的表达［J］.解剖学报,2013,44(5):694-698.

［33］Dong L, Chen L, Shi T, et al. Combined monitoring of intracranial pressure and bispectral index in patients with severe craniocerebral trauma post-operatively ［J］. Clin Neurol Neurosurg, 2016, 148:42-44.

［34］Mueller K, Sacher J, Arelin K, et al. Overweight and obesity are associated with neuronal injury in the human cerebellum and hippocampus in young adults: a combined MRI, serum marker and gene expression study ［J］. Transl Psychiatry，2012, 2(12):e200.

［35］Li BC, Li Y, Xu C, et al.Blast-induced traumaticbrain injury of goats in confined space ［J］.Neurol Res, 2014,36(11): 974-982.

［36］Krohn M, Dressler J, Bauer M, et al. Immunohistochemical Investigation of S100 and NSE in cases of traumatic brain injury and its application for survival time determination［J］. J Neurotrauma, 2015, 32(7):430-440.

［37］Ono T, Sasajima T, Oda M, et al. Cerebellar hemangioblastoma with marked pleomorphism: a case report［J］. No Shinkei Geka, 2012, 40(7):643-650.

［38］Kakkar A, Sable M, Suri V, et al. Cerebellar liponeurocytoma, an unusual tumorof the central nervous system ultrastructural examination［J］. Ultrastruct Pathol, 2015, 39(6):419-423.

［39］Yilmaz N, Karaali K, Ozdem S, et al. Elevated S100B and neuron specific enolase levels in patients with migraine-without aura: evidence for neurodegeneration［J］? Cell Mol Neurobiol, 2011, 31(4):579-585.

［40］Hahn DK, Geocadin RG, Greer DM. Quality of evidence in studies evaluating neuroimaging for neurologic prognostication in adult patients resuscitated from cardiac arrest［J］. Resuscitation, 2014, 85(2):165-172.

［41］Berger RP, Bazaco MC, Wagner AK, et al. Trajectory analysis of serum biomarker concentrations facilitates outcome prediction after pediatric traumatic and hypoxemic brain injury ［J］. Dev Neurosci, 2010, 32(5-6):396-405.

［42］Schroeter M L, Mueller K, Arelin K, et al. Serum neuron-specific enolase is related to cerebellar connectivity: a resting-state functional magnetic resonance imaging pilot study［J］. J Neurotrauma, 2015, 32(17):1380-1384.

［43］Kleindienst A, Meissner S, Eyupoglu IY, et al. Dynamics of S100B release into serum and cerebrospinal fluid following acute brain injury［J］.Acta Neurochirur Suppl, 2010, 106:247-250.

［44］Marquardt G, Setzer M, Szelenyi A, et al. Prognostic relevance of serial S100b and NSE serum measurements in patients with spinal intradural lesions［J］. Neurol Res, 2013, 31(3):265-269.

［45］Charles OA, Patrick IS, Godwin AO. Jobelynsupplement lowered neuronal degeneration: significance of altered p53 and γ- enolase protein expressions in prefrontal cortex of rat exposed to ethanol［J］. Ann Neurosci, 2016, 23(3):139-148.

［46］Zhang B, Huang Y, Su Z, et al. Neurological, functional, and biomechanical characteristics after high-velocity behind armor blunt trauma of the spine［J］. J Trauma, 2011, 71(6):1680-1688.

［47］Ahadi R, Khodagholi F, Daneshi A, et al. Diagnostic value of serum levels of GFAP, pNF-H, and NSE compared with clinical findings in severity assessment of human traumatic spinal cord injury［J］. Spine (Phila Pa 1976), 2015,40(14):E823-E830.

［48］Oh J, You Y, Yun Y, et al. A gene and neural stem cell therapy platform basedon neuronal cell type-inducible gene overexpression［J］.Yonsei Med J, 2015, 56(4):1036-1043.