肝窦内皮细胞的窗孔调控与脂肪肝形成的研究进展

王巧稚 樊婧 张卫光*

doi:10.16098/j.issn.0529-1356.2017.06.023

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解剖学报 ›› 2017, Vol. 48 ›› Issue (6) : 766-770. DOI: 10.16098/j.issn.0529-1356.2017.06.023

综述

肝窦内皮细胞的窗孔调控与脂肪肝形成的研究进展

王巧稚^1.2 樊婧¹ 张卫光^1*

作者信息 +

Research progress on fenestrated regulation of hepatic sinusoidal endothelial cells and hepatic steatosis

WANG Qiao-zhi ^1.2 FAN Jing¹ZHANG Wei-guang^1*

Author information +

文章历史 +

摘要

衬贴于肝血窦的肝窦内皮细胞具有无隔膜的窗孔，并汇聚成肝筛。窗孔相当于可选择超滤系统，有利于调控肝细胞与肝窦血液的物质交换，尤其是在脂质代谢方面，窗孔结构异常是脂质代谢紊乱的重要因素。本文就窗孔的超微结构、开窗机制和调控因素以及与脂肪肝相关联系的进展做一综述。

Abstract

Liver sinusoidal endothelial cells (LSECs) are gossamer-thin cells that line the hepatic sinusoid and they are perforated with pores called fenestrations clustered in sieve plates. There is growing evidence that fenestrations may work as a permselective ultrafiltration installation which is important for the hepatic to uptake substrates, particularly metabolism of lipoproteins. Abnormal fenestratel structure had been considered as a vital factor to liver lipid metabolism disorders. This review mainly focused on the relationship between ultrastructure of the fenestration, the fenestrated mechanism, the regulation factor of fenestration, and hepatic steatosis.

导出引用

王巧稚樊婧张卫光. 肝窦内皮细胞的窗孔调控与脂肪肝形成的研究进展[J]. 解剖学报. 2017, 48(6): 766-770 https://doi.org/10.16098/j.issn.0529-1356.2017.06.023

WANG Qiao-zhi FAN Jing ZHANG Wei-guang. Research progress on fenestrated regulation of hepatic sinusoidal endothelial cells and hepatic steatosis[J]. Acta Anatomica Sinica. 2017, 48(6): 766-770 https://doi.org/10.16098/j.issn.0529-1356.2017.06.023

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