细胞自噬在宫颈癌中的相关研究进展

童焰 谭布珍* 方玉婷 赖智清 王玉 王小红

doi:10.16098/j.issn.0529-1356.2017.01.020

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解剖学报 ›› 2017, Vol. 48 ›› Issue (1) : 111-114. DOI: 10.16098/j.issn.0529-1356.2017.01.020

综述

细胞自噬在宫颈癌中的相关研究进展

童焰¹ 谭布珍^1* 方玉婷¹ 赖智清² 王玉¹ 王小红³

作者信息 +

Related research progress of autophagy in cervical cancer cells

TONG Yan¹TAN Bu-zhen ^1* FANG Yu-ting¹ LAI Zhi-qing² WANG Yu¹WANG Xiao-hong³

Author information +

文章历史 +

摘要

细胞自噬指细胞利用溶酶体降解细胞质中错误折叠的蛋白质及受损细胞器等，重新利用降解物质及胞内有害物质的过程，以维持细胞内环境稳定。正常状态下细胞的自噬维持在低水平，当细胞处在不利因素条件下，自噬也会被激活应对不利因素。自噬在肿瘤发生、发展、转移、复发、药物抵抗等方面有着重要作用，但自噬在这些方面的详细机制仍不清楚。我们在文中对宫颈癌细胞中自噬相关基因的表达情况进行了阐述，自噬治疗在宫颈癌中具有重要的应用前景。

Abstract

Cell autophagy refers to use lysosomes to degrade the misfolded proteins and the damaged organelles in the cytoplasm. This process can reuse the intracellular degradation substances in order to maintain stable environment in the cell.Normal cells maintain at a low level of autophagy. When a cell is under the condition of unfavorable factors， its autophagy can be activated against unfavorable factors.Autophagy plays an important role in cancer occurrence,development, metastasis, recurrence and drug resistance, but the detailed mechanism of autophagy in these areas is still unclear.In this paper, the autophagy\| related genes in cervical cancer cells and their application in cervical cancer treatment are reviewed.

导出引用

童焰谭布珍方玉婷赖智清王玉王小红. 细胞自噬在宫颈癌中的相关研究进展[J]. 解剖学报. 2017, 48(1): 111-114 https://doi.org/10.16098/j.issn.0529-1356.2017.01.020

TONG Yan TAN Bu-zhen FANG Yu-ting LAI Zhi-qing WANG Yu WANG Xiao-hong. Related research progress of autophagy in cervical cancer cells[J]. Acta Anatomica Sinica. 2017, 48(1): 111-114 https://doi.org/10.16098/j.issn.0529-1356.2017.01.020

参考文献

［1］Thabet M，Hemida R，HasanM，et al.Human papillomavirus(HPV) is not the main cause of preinvasive and invasive cervical cancer among patientsin Delta Regin，Egypt［J］.J Expther Onclol，2014,10(4):247-253.

［2］Obel J, McKenzie X, Buenconsejo-Lum LE，et al.Mapping HPV vaccination and cervical cancer screening practice in the pacific region-strengthening national and regional cervical cancer prevention［J］.Asian Pac J Cancer Prev, 2015, 16(8): 3435-3442.

［3］Levine B,Packer M,Codogno P，et al.Development of autophagy inducers in clinical medicine［J］J Clin Invest, 2015, 125(1): 14-24.

［4］Zhang J,Zhao MM,Li R,et al.Expression of microtubule-associated protein 1 light chain 3 and Beclin-1 in alveolar macrophages of silicosis rats［J］.Acta Anatomica Sinica, 2014，45（5）:646-651.（in Chinese）

张娟,赵曼曼,李冉，等，微管相关蛋白1轻链3及Beclin-1在硅沉着病大鼠肺泡巨噬细胞中的表达微管相关蛋白1轻链3及Beclin-1在硅沉着病大鼠肺泡巨噬细胞中的表达［J］,解剖学报，2014，45（5）:646-651.

［5］Wang T, Gao YT, Wang ChL, et al. The correlation of the occurrence of autophagy between with the expression of HMGB1,the location in starvation Lewis cells ［J］. Journal of Immunology, 2013, (12): 1013.（in Chinese）

汪汀，高云涛，王承琳，等. 饥饿状态下Lewis细胞HMGB1的表达、定位与细胞自噬发生的相关性研究［J］.免疫学杂志，2013，(12):1013.

［6］Liu Y, Levine B.Autosis and autophagic cell death: the dark side of autophagy［J］. Cell Death Differ, 2015, 22(3): 367-376.

［7］Huang YH, Al-aidaroos AQ, Yuen HF, et al.A role of autophagy in PTP4A3-driven cancer progression［J］Autophagy, 2014,10(10):1787-1800.

［8］Wilkinson DS, Jariwala JS, Anderson E，et al.Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy［J］.Mol Cell, 2015,57(1): 55-68.

［9］Chunrong H，Baocun S，Wei W，et al.Overexpression of micrntubule associated protein-1 light chain 3 is associated with melanoma metastasisand vasculogenic mimicry［J］.Tohoku J ExpMed，2011，223(22)：243-251.

［10］Tamura N, Oku M, Sakai Y. Atg8 regulates vacuolar membrane dynamics in a lipidation-independent manner in Pichia pastoris［J］. J Cell Sci, 2010, 123(Pt23):4107-4116.

［11］Hu YF，Lei X，Zhang HY，et al.Expressions and clinical significance of autophagy-related markers Beclin1，LC3and EGFR in human cervicalsquamous cell carcinoma［J］.Onco Targets Ther, 2015，8（3）:2243-2249.

［12］Zhu W， Pan X， Li F， et al.Expression of Beclin 1 and LC3 in FIGO stage I-II cervical squamous cell carcinoma and relationship to survival［J］.Tumour Biol, 2012,33(5):1653-1659.

［13］Zhong Y,Morris DH, Jin L,et al.Nrbf2 Protein Suppresses Autophagy by Modulating Atg14LProteincontaining Beclin 1-Vps34 Complex Architecture and Reducing Intracellular hosphatidylinositol-3 Phosphate Levels［J］.J Biol Chem, 2014,289(38): 26021-26037.

［14］Sun Y，Liu JH，Jin L，et al.Beclin 1 influences cisplatin-induced apoptosis in cervical cancer CaSki cells by mitochondrial dependent pathway［J］.Int J Gynecol Cancer, 2012，22(7):1118-1124.

［15］Lindqvist LM,Heinlein M,Huang DC, et al. Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting［J］.Proc Natl Acad Sci USA, 2014, 111(23): 8512-8517.［16］Cheng HY，Zhang YN，Wu QL，et al.Expression of beclin 1 an autophagy-related protein，in human cervical carcinoma and its clinical significance［J］.Eur J Gynaecol Oncol, 2012,33(1):15-20.

［17］He C, Mao D, Hua G，et al.The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression［J］.EMBO Mol Med, 2015,7(11): 1426-1449.

［18］Tanton C, Soldan K, Beddows S,et al.High-risk human papillomavirus (HPV) infection and cervical cancer prevention in Britain: Evidence of differential uptake of interventions from a probability survey Cancer［J］. Epidemiol Biomarkers Prev, 2015,24(5): 842-853.

［19］Wang HY， Yang GF， Huang YH，et al. Reduced expression of autophagy markers correlates with high-risk human papillomavirus infection in human cervical squamous cell carcinoma［J］. Oncol Lett, 2014,8(2):1492-1498.

［20］Meijer AJ,Lorin S, Blommaart EF, et al. Regulation of autophagy by amino acids and MTOR-dependent signal transduction［J］. Amino Acids, 2015, 47(6): 2037-2063.

［21］Surviladze Z,Sterk RT,DeHaro SA,et al.Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy［J］.J Virol, 2013,87(6):2508-2517.

［22］Chen TC， Hung YC， Lin TY， et al. Human papillomavirus infection and expression of ATPase family AAA domain containing 3A，a novel anti-autophagy factor in uterine cervical cancer［J］. Int J Mol Med, 2011：28(5):689-696.

［23］Sukumaran P, Schaar A, Sun Y. Singh BB2 functional role of TRP channels in modulating ER stress and autophagy［J］.Cell Calcium, 2016,3(16):143-160.

［24］Iurlaro R, Muoz PC.Cell death induced by endoplasmic reticulum stress［J］. Febs Journal, 2015,283(14):2640-2652.

［25］Wang ZH, Wang YJ, Huo JL，et al.The studies of E6 protein of HPV 16 induce the autophagy of cervical cancer C33A through endoplasmic reticulum stress pathway［J］. Cancer Research and Clinical, 2015,27 (6): 371-374.(in chinese）

王赞宏，王宇娟，霍俊玲, 等.人乳头瘤病毒1 6 E6蛋白通过内质网应激途径诱导子宫颈癌C33A细胞自噬的研究［J］.肿瘤研究与临床，2015，27(6):371-374.

［26］Xie B， Chen J， Liu B， et al. Klotho acts as a tumor suppressor in cancers［J］. Pathol Oncol Res，2013，19(4):611-617.

［27］Aviel-Ronen S, Rubinek T, Zadok O, et al.Klotho expression in cervical cancer: differential expression in adenocarcinoma and squamous cell carcinoma［J］.J Clin Pathol, 2016, 69(1):53-57.

［28］Liu H，Fergusson MM，Castilho RM，et al，Augmented wnt signaling in amammalian model of accelerated aging［J］.Science，2007，317(5)：803-806.

［29］Sun H, Gao Y, Lu K,et al.Overexpression of Klotho suppresses liver cancer progression and induces cell apoptosis by negatively regulating wnt/β-catenin signaling pathway［J］.World J Surg Oncol, 2014, 13(1):1-8.

［30］Malanehi L，Peinado H，Kassen D，et al.Cutaneous cancer stem cell maintenance isdependent onbeta-eateninsignalling［J］.Nature，2008，452(18)：650-653.

［31］Xiaowei Tang,1,2,4 Yun Wang,1,4 Zhining Fan，et al.Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular［J］. Carcinoma.Lab Invest, 2016, 96(2): 197-205.

［32］Lee J，Jeong DJ，Kim J，et al.The anti\|aging gene KLOTHO is anovel target for epigenetic silencing in human cervical carcinonla［J］. Mol Cancer，2010，9：109.