巨噬细胞的极化及功能调控

宮甜甜 黄少刚 张玥 李佳 雷蕾 单智焱*

doi:10.16098/j.issn.0529-1356.2017.01.019

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解剖学报 ›› 2017, Vol. 48 ›› Issue (1) : 106-110. DOI: 10.16098/j.issn.0529-1356.2017.01.019

综述

巨噬细胞的极化及功能调控

宮甜甜黄少刚张玥李佳雷蕾单智焱*

作者信息 +

Polarization and functional regulation of macrophage

GONG Tian-tian HUANG Shao-gang ZHANG Yue LI Jia LEI Lei SHAN Zhi-yan*

Author information +

文章历史 +

摘要

巨噬细胞在体内分布极广，具有高度可塑性，并在机体的发育及内环境的平衡中起到重要作用。应激条件下，巨噬细胞发生极化，极化后的巨噬细胞亚型可以细致调节及回应各种不同的刺激，对炎症反应或疾病的发展及组织器官的修复程度起着关键性的作用，具有重要的临床应用价值。我们在文中概述了巨噬细胞的极化分类，作用机制及不同环境下巨噬细胞的功能转换，为巨噬细胞极化研究提供理论基础。

Abstract

Macrophages have the great plasticity in various tissues in vivo, which play important roles in the development and homeostasis. In response to certain inductors, macrophages can change their phenotype and result in polarization. Polarized macrophages can react to the immune response and participate in tissue repair and remodeling, which have the significant clinic application value. In this review, the classification, regulation mechanism and reprogramming of polarization are addressed, which may provide a theory basis for research of macrophage polarization.

导出引用

宮甜甜黄少刚张玥李佳雷蕾单智焱. 巨噬细胞的极化及功能调控[J]. 解剖学报. 2017, 48(1): 106-110 https://doi.org/10.16098/j.issn.0529-1356.2017.01.019

GONG Tian-tian HUANG Shao-gang ZHANG Yue LI Jia LEI Lei SHAN Zhi-yan. Polarization and functional regulation of macrophage[J]. Acta Anatomica Sinica. 2017, 48(1): 106-110 https://doi.org/10.16098/j.issn.0529-1356.2017.01.019

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