细胞自噬机制开启疾病治疗新途径

王海杰 谭玉珍*

doi:10.16098/j.issn.0529-1356.2017.01.018

PDF(143 KB)

解剖学报 ›› 2017, Vol. 48 ›› Issue (1) : 103-105. DOI: 10.16098/j.issn.0529-1356.2017.01.018

综述

细胞自噬机制开启疾病治疗新途径

王海杰谭玉珍*

作者信息 +

Mechanism of autophagy opens a new way for treatment of diseases

WANG Hai-jie TAN Yu-zhen*

Author information +

文章历史 +

摘要

自噬是指细胞内细胞器和蛋白质等在溶酶体被降解及其降解产物被重新利用的过程。日本科学家大隅良典（Yoshinori Ohsumi）发现了15个自噬相关基因并阐述了自噬机制，获得2016年诺贝尔生理学与医学奖。他的开创性研究成果为探讨细胞自噬的生理和病理作用奠定了重要基础，并为通过调节细胞自噬治疗疾病开辟了新途径。自噬是一种普遍性细胞反应，正常情况下细胞自噬水平很低，受生理或病理性刺激后自噬水平显著升高。自噬相关基因缺失或自噬功能障碍时可导致某些疾病的发生。近来，人们试图通过激活或抑制细胞自噬预防和治疗自噬障碍相关性疾病。

Abstract

Autophagy summarizes all processes in which intracellular material is degraded within the lysosome and where the macromolecular constituents are recycled. Japanese scientist Yoshinori Ohsumi discovered 15 autophagy-related genes (ATG) and elaborated autophagic mechanisms. He has won the 2016 Nobel Prize in Physiology or Medicine. His pioneering research achievements provide an important base for studying physiological and pathological effects of cell autophagy and open a new way for treatment of diseases by modulating autophagy. Autophagy is a common cellular response. The level of autophagy is low in normal condition, while physiological and pathological stimulations up-regulate autophagy significantly. ATG deletion or autophagic disfunction may cause some diseases. Recently, prevention and treatment of autophagic disfunction-related diseases by activating or inhibiting cell autophagy have been tried.

导出引用

王海杰谭玉珍. 细胞自噬机制开启疾病治疗新途径[J]. 解剖学报. 2017, 48(1): 103-105 https://doi.org/10.16098/j.issn.0529-1356.2017.01.018

WANG Hai-jie TAN Yu-zhen. Mechanism of autophagy opens a new way for treatment of diseases[J]. Acta Anatomica Sinica. 2017, 48(1): 103-105 https://doi.org/10.16098/j.issn.0529-1356.2017.01.018

参考文献

［1］Enserink M, Pennisi E. Nobel honors discoveries in how cells eat themselves［J］. Science, 2016, 354(6308): 20.

［2］van Noorden R, Ledford H. Medical award for cell recycling［J］. Nature, 2016, 538(7623):18-19.

［3］Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)［J］. Autophagy, 2016, 12(1):1-222.

［4］Wang HJ, Tan YZh. Morphological features and functional implications of autophagy［J］. Acta Anatomica Sinica, 2009, 40(5): 844-849. (in Chinese)

王海杰，谭玉珍.细胞自噬的形态学特征和功能意义［J］.解剖学报,2009，40（5）：844-849.

［5］Wang HJ, Tan YZh. Functional implication of lymsosomal pathways for cell autophagy［J］ Chinese Bulletin of Life Science, 2011, 23(8): 723-729. (in Chinese)

王海杰，谭玉珍.溶酶体途径在细胞自噬过程中的功能意义［J］.生命科学,2011，23（8）：723-729.

［6］Wang HJ, Zhang D, Tan YZ, et al. Autophagy in endothelial progenitor cells is cytoprotective in hypoxic conditions［J］. Am J Physiol Cell Physiol, 2013, 304(7): C617-C626.

［7］Zhou P, Tan YZ, Wang HJ, et al. Cytoprotective effect of autophagy on phagocytosis of apoptotic cells by macrophages［J］. Exp Cell Res, 2016, 348(2): 165-176.

［8］Ravikumar B, Sarkar S, Davies JE, et al. Regulation of mammalian autophagy in physiology and pathophysiology［J］. Physiol Rev, 2010, 90(4):1383-1435.

［9］Choi AMK, Ryter SW, Levine B. Autophagy in human health and disease［J］. New Engl J Med, 2013, 368(7):651-662.

［10］Rubinsztein DC, Codogno P, Levine B. Autophagy modulation as a potential therapeutic target for diverse diseases［J］. Nat Rev Drug Discov, 2012, 11(9): 709-730.

［11］Wang HJ,Tan YZh. Progress and application of techniques for ivestigating cell autophagy［J］. Chinese Journal of Cell Biology, 2011, 33(7): 816-821. (in Chinese)

王海杰，谭玉珍.细胞自噬研究技术进展及其应用［J］.中国细胞生物学学报, 2011，33（7）：816-821.