目的 探讨医学影像导出为三维模型并建立交互3D PDF文件。 方法 使用了3个开源软件包括3D Slicer、MeshLab和TeXstudio，进行感兴趣区体裁剪、模型分割和3D PDF制作。 结果 3D Slicer可以多种方法进行模型分割，MeshLab可以进行模型清理和分割，并在导出U3D格式文件的同时生成TEX格式文件，通过TeXstudio编译生成3D PDF文件。 结论 这种方法步骤简单易学，推广普及容易，有利于促进更多3D PDF的制作和使用。

Objective To discuss how to convert medical images into a 3D model and embed them in a Portable Document Format (PDF) file. Methods Three opensource programs, 3D Slicer,MeshLab,TeXstudio, were used to volume clipping with ROI for segmentation models and embed them in 3D PDF. Results 3D Slicer used a variety of methods for model segmentation,Meshlab carried out model cleaning and segmentationand, generated TEX format files, exported U3D format files,and then generated 3D PDF files that were compiled by TeXstudio. Conclusion The method introduced in this paper is simple and easy to learn, and is helpful to promote the production and use of 3D PDF.