浙江汉族群体指长比与寻常性痤疮的相关性

汤挺兵* 叶先才 范晓文陈光平汪晓庆 陈欢

doi:10.16098/j.issn.0529-1356.2016.05.021

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解剖学报 ›› 2016, Vol. 47 ›› Issue (5) : 693-696. DOI: 10.16098/j.issn.0529-1356.2016.05.021

人类学

浙江汉族群体指长比与寻常性痤疮的相关性

汤挺兵^1* 叶先才² 范晓文¹陈光平¹汪晓庆¹ 陈欢³

作者信息 +

Correlativity between digit ratio and acne vulgaris among Han population in Zhejiang province

TANG Ting-bing ^1* YE Xian-cai² FAN Xiao-wen¹CHEN Guang-ping¹WANG Xiao-qing¹CHEN Huan³

Author information +

文章历史 +

摘要

目的探讨浙江汉族群体指长比与寻常性痤疮（AV）的相关性。方法采用直接测量法，用电子游标卡尺测量浙江汉族AV患者和健康人群左右手掌侧第2～5手指长度（拇指除外），AV严重程度分级标准采用国际分类法。结果对浙江汉族261例AV患者组（女性占74.3%）和381例健康对照组(女性占59.6%)、年龄在18～25岁的数据进行了分析，健康组和AV患者组的左右手指长比均值趋势都为2D∶3D＜2D∶4D＜3D∶4D＜2D∶5D＜4D∶5D＜3D∶5D，AV患者组中女性患者2D∶4D、3D∶4D比值低于女性健康组，差异具有显著性（P＜0.01或P＜0.05），女性的AV患者2D∶3D、2D∶5D、4D∶5D、3D∶5D比值与女性健康组无差异；男性的AV患者与男性健康组之间各指长比值差异不显著。结论浙江汉族女性2D∶4D、3D∶4D指长比低比值与寻常性痤疮的发病有关。

Abstract

Objective To study if acne vulgaris (AV) correlates with the digit ratio among Han population in Zhejiang province. Methods Adopt direct measurement method was used to measure the digit length 2D to 5D of AV patients and healthy people among Han Population in Zhejiang Province with the electronic digital caliper. Levels of AV severity were determined according to the international classification. Results An analysis was made on the digit lengths of 261 AV patients (74.3% are female) and 381 healthy people (59.6% are female) aging from 18 to 25 years.2D∶4D and 3D∶4D of female AV patients were significantly lower than female healthy people（P＜0.01 or P＜0.05）.2D∶3D，2D∶5D，4D∶5D and 3D∶5D of AV patients group and healthy group were almost same. The ratio of all digits had not too much differences in male AV patients group and male healthy group. Conclusion The onset of AV among Female Han Population in Zhejiang Province correlates with their low ratios of 2D∶4D，3D∶4D.

导出引用

汤挺兵叶先才范晓文陈光平汪晓庆陈欢. 浙江汉族群体指长比与寻常性痤疮的相关性[J]. 解剖学报. 2016, 47(5): 693-696 https://doi.org/10.16098/j.issn.0529-1356.2016.05.021

TANG Ting-bing YE Xian-cai FAN Xiao-wen CHEN Guang-ping WANG Xiao-qing CHEN Huan. Correlativity between digit ratio and acne vulgaris among Han population in Zhejiang province[J]. Acta Anatomica Sinica. 2016, 47(5): 693-696 https://doi.org/10.16098/j.issn.0529-1356.2016.05.021

参考文献

［1］Zhang XJ. Dermatology and Venereal Disease［M］.8th ed. Beijing: People’s Medical Publishing House (PMPH)，2013:175-177. (in Chinese)

张学军.皮肤性病学［Ｍ］.第8版.北京：人民卫生出版社，2013：175-177.

［2］Kaur J，Sehgal VK，Gupta AK，et al.A comparative study to evaluate the efficacy and safety of combination topical preparations in acne vulgaris［J］.Int J Appl Basic Med Res，2015,5(2)：106,110.

［3］Taylor M, Gonzalez M, Porter R. Pathways to inflammation: acne pathophysiology［J］.Eur J Dermatol,2011,21(3): 323-333.

［4］Thiboutot DM. Acne. An overview of clincal research findings［J］. Dermatol clin, 1997, 15(1)：97-109.

［5］Yu ZhJ，Lu J, Duan XS, et al.Expression of androgen receptor in lesions of patients with acne vulgaris［J］. China Journal of Leprosy and Skin Diseases，2008，24(6)：433-435.(in Chinese)

于中蛟, 陆洁，段昕所，等.痤疮患者皮损处雄激素受体的表达［J］.中国麻风皮肤病杂志，2008，24(6)：433-435.

［6］Zouboulis CC.Acne vulgaris.The role of hormones［J］.Der Hautarzt，2010，61(2)：4046-4049.

［7］Pang Y，He ChD，Liu Y，et al. Length of CAG repeat in exon l of the androgen receptor gene is associated with the development of acne［J］. Chinese Journal of Dermatology, 2008, 41(12): 796-799. (in Chinese)

庞莹，何春涤，刘勇，等. 雄激素受体基因第一外显子CAG重复序列长度多态性与痤疮的相关性［J］.中华皮肤科杂志,2008, 41(12): 796-799.

［8］Manning JT. Digit Ratio: A Pointer to Fertility, Behavior and Health［M］.London: Rutgers University Press,2002:1-141.

［9］Manning JT, Callow M，Bundred PE. Finger and toe ratios in humans and mice: implications for the aetiology of diseases influenced by HOX genes［J］. Med Hypotheses，2003，60(3)：340-343.

［10］Xi HJ，Zhao H， Li WH，et al. Primary analysis of current studies on the digit ratio［J］.Acta Anatomica Sinica，2012，43（4）：569-573.(in Chinese)

席焕久，赵红，李文慧，等. 对指长比研究现状的初步分析［J］.解剖学报，2012，43（4）:569-573.

［11］Loehlin JC，Mcfadden D，Medland SE，et al. Population differences in finger-length ratios: ethnicity or latitude ［J］ ? Arch Sex Behav，2006，35(6)：739-742.

［12］Breedlove SM. Minireview: organizational hypothesis: instances of the fingerpost［J］. Endocrinology，2010, 151(9):4116-4122.

［13］Manning JT. Resolving the role of prenatal sex steroids in the development of digit ratio［J］. Proc Natl Acad Sci USA, 2011,108(39):16143-16144.

［14］Dressler SG, Voracek M. No association between two candidate markers of prenatal sex hormones: digit ratios (2D∶4D and other) and fingerridge counts［J］.Dev Psychobiol,2011,53(1):69-78.

［15］Okten A, Kalyoncu M, Yaris N. The ratio of second-and fourth-digit lengths and congenital adrenal hyperplasia due to 21-hydroxylase deficiency［J］.Early Hum Dev，2002，70(1-2):47-54.

［16］Brown WM, Hines M, Fane BA, et al. Masculinized finger length patterns in human males and females with congenital adrenal hyperplasia［J］. Horm Behav,2002, 42(4): 380-386.［17］Chai XJ, Jacobs LF. Digit ratio predicts sense of direction in women［J］. PLoS One, 2012, 7(2): e32816.

［18］Berenbaum SA, Bryk KK, Nowak N, et al. Fingers as a marker of prenatal androgen exposure［J］. Endocrinology, 2009, 150(11): 5119-5124.

［19］Minto CL, Liao KL, Conway GS, et al. Sexual function in women with complete androgen insensitivity syndrome［J］. Fertil Steril, 2003, 80(1):157-164.

［20］Manning JT, Bundred PE, Newton DJ, et al. The second to fourth digit ratio and variation in the androgen receptor gene［J］. Evol Hum Behav,2003,24(6):399-405.

［21］Zhao B. Chinese Journal of Clinical Dermatology［M］. Nanjing:Jiangsu Science and Technology Press, 2009:1165-1166. (in Chinese)

赵辨.中国临床皮肤病学［M］.南京：江苏科学技术出版社，2009：1165-1166.

［22］Manning JT, Fink B. Digit ratio (2D∶4D), dominance, reproductive success, asymmetry, and sociosexuality in the BBC Internet Study［J］. Am J Hum Biol, 2008, 20(4):451-461.

［23］Bilgi? ?, Dogˇdu M, IslamogˇluGK, et al. The relationship between the second to fourth digit ratio and acne vulgaris［J］.J Eur Acad Dermatol Venereol,2014,28(10):1340-1343.

［24］Berenbaum SA. Effects of early androgens on sex-typed activities and interests in adolescents with congenital adrenal hyperplasia［J］.Horm Behav,1999,35(1):102-110.

［25］Abbott DH, Barnett DK, Bruns CM, et al. Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome ［J］? Hum Reprod Update, 2005,11(4):357-374.

［26］Ventura T, Gomes MC, Pita A, et al. Digit ratio (2D∶4D) in newborns:influencess of prenatal testosterone and maternal environment［J］.Early Hum Dev, 2013,89(2):107-112.