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内质网应激中活化转录因子6通路及相关调控因子对未折叠蛋白反应的调控
Research on activating transcription factor 6 pathway and its related factors’ regulation on unfolded protein reaction in endoplasmic reticulum stress
目的 内质网应激在多种疾病的发病机制中起到关键作用，持续或强烈的内质网应激反应可诱导细胞凋亡。作为一种内质网跨膜蛋白，活化转录因子6（ATF6）可以感受内质网应激并传递信号诱导未折叠蛋白反应。我们主要对ATF6通路以及其调控凋亡的机制进行综述，重要概述了相关激活剂和抑制剂,希望能为一些神经退行性疾病的治疗提供参考。
Endoplasmic reticulum stress plays a key role in many diseases’ pathogenesis. Continuous or intense endoplasmic reticulum stress response can induce cell apoptosis. As an endoplasmic reticulum transmembrane protein, activating transcription factor 6(ATF6) can transfer signals to induce unfolded protein response. This review summarizes the ATF6 pathway and its mechanism of regulating apoptosis and pays attention to the related activators and inhibitors, in order to provide background research data for the neurodegenerative disease.
内质网应激 / 未折叠蛋白反应 / 活化转当因子6 / 激活剂 / 抑制剂
Endoplasmic reticulum stress / Unfolded protein reaction / Activating transcription factor 6 / Activator / Inhibitor
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